三陰性（triple negative）乳癌
三陰性（triple negative）乳癌的定義，包含雌激素受體（estrogen receptor）陰性、孕激素受體（progesterone receptor）陰性和第二型人類表皮生長因子接受體（human epidermal growth factor receptor 2）陰性。
Triple-negative breast cancer (TNBC) is a type of breast cancer that is characterized by the absence of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) expression.
通常這些受體和乳癌細胞的生長和分化有著關聯的關係：
These receptors are typically associated with the growth and differentiation of breast cancer cells:
雌激素受體 (ER) 和 孕激素受體 (PR) 是激素受體，可結合雌激素和孕激素，促進乳癌細胞的生長。
ER and PR are hormone receptors that can bind to estrogen and progesterone, respectively, and promote the growth of breast cancer cells.
人類表皮生長因子受體 2 (HER2) 是一種酪氨酸激酶受體，可促進乳癌細胞的生長和分化。
HER2 is a tyrosine kinase receptor that can promote the growth and differentiation of breast cancer cells.
三陰性乳癌佔所有乳癌的 15%-20%，通常更具侵襲性，預後更差。
TNBC accounts for 15-20% of all breast cancers and is typically more aggressive and has a worse prognosis.
然而細胞角蛋白 (cytokeratin) 是一種中間絲蛋白，在細胞骨架中起著重要作用。
However, cytokeratin is an intermediate filament protein that plays an important role in the cell cytoskeleton.
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